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WHAT IS CBD?
- Cannabidiol (CBD) is the second major cannabinoid found in cannabis plants like hemp and marijuana. Unlike the other major cannabinoid THC, CBD is non-psychoactive. The effects of CBD include: alerting at low doses, sedating at high doses, reduces pain, relaxes muscle spasms, potent anti-inflammatory, stops nausea/vomiting, reduces anxiety/depression, counters psychotic thoughts, anti-oxidant, anti-convulsant, neuro-protectant, and anti-tumor effects.
- The endocannabinoid system acts a homeostasis regulator in the body. Its purpose is to maintain balance.
- Endocannabinoids (cannabinoids produced naturally in the body of mammals) are not neurotransmitters. Endocannabinoids are neuromodulators. They are released on demand to alter the activity of neurotransmitters. A good example is glutamate. Glutamate is a primary, stimulatory neurotransmitter.
- When glutamate is present in excessive amounts, pain and cell death can occur. The release of endocannabinoids functions as a stopping mechanism for the release of glutamate.
THC and CBD can act in the same way as our own endocannabinoids. Source: Introduction to the Endocannabinoid System.
- The endocannabinoid system is the collection of cannabinoid receptors, endocannabinoids, and enzymes involved in the production and break down of endocannabinoids.
Endocannabinoids are naturally occurring cannabinoids found within our body. The two most studied endocannabinoids are anandamide and 2-AG. The two most studies cannabinoid receptors are CB1 and CB2.
CB1 receptors are located mostly in the brain and CB2 receptors are located mostly throughout the immune system.
CBD: How does it work with the Endcannabinoid System?
- Cannabinoid receptors have been found in many different glands of the endocrine system. By activating receptors in the pineal gland, CBD may help stimulate the secretion of sleep hormones like melatonin, ultimately affecting sleep and energy levels.
- Cannabinoids generally work by binding to our bodys cannabinoid receptors (CB1 or CB2). Cannabinoids like CBD can work in other ways by targetting non cannabinoid receptors in the body.
- CB1 receptors are located primarily in the central nervous system (the brain and spinal chord).
- CB2 receptors are located primarily in the immune system.
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